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Gorlin syndrome: a case report.

K Patil1, V G Mahima, B Gupta

  • 1Department of Oral Medicine and Radiology, JSS Dental College and Hospital, Mysore-15, India.

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|December 6, 2005
PubMed
Summary
This summary is machine-generated.

Gorlin syndrome, an inherited disorder, commonly causes basal cell carcinomas and jaw cysts. Early diagnosis in children often relies on identifying specific oral abnormalities.

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Area of Science:

  • Genetics
  • Dermatology
  • Oral and Maxillofacial Surgery

Background:

  • Gorlin syndrome is an autosomal dominant inherited disorder.
  • It is known for high penetrance and variable expressivity.
  • Key features include basal cell carcinomas, odontogenic keratocysts, and skeletal anomalies.

Observation:

  • The syndrome presents with diverse manifestations affecting skin, central nervous system, and skeletal systems.
  • Lesser-known clinical features are documented in medical literature.
  • Diagnosis in childhood is often indicated by specific oral abnormalities.

Findings:

  • This report details a case of Gorlin syndrome.
  • A comprehensive review of existing literature is provided.
  • The case highlights the diagnostic importance of oral manifestations in pediatric patients.

Implications:

  • Understanding the varied clinical spectrum is crucial for timely diagnosis and management.
  • Early identification through oral examination can significantly impact patient outcomes.
  • Further research into the genetic and clinical aspects of Gorlin syndrome is warranted.