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Updated: Aug 14, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis
Guillaume Breton1, Homa Adle-Biassette, Audrey Therby
1Department of Infectious and Tropical Diseases, Hôpital Bichat-Claude Bernard, Paris, France.
Abstract:
Four HIV-1-infected patients presented with unusual clinical manifestations in the course of disseminated histoplasmosis, including liver abscesses, compressive lymphadenitis, intestinal obstruction, uveitis and arthritis within a median of 45 days after initiation of highly active antiretroviral therapy (HAART). They had a median increase of 106 CD4 cells/mul and granulomas with caseation in three. Partial immune reconstitution induced by HAART during disseminated histoplasmosis either related to the variety capsulatum or duboisii may be associated with immune reconstitution inflammatory syndrome.
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