Related Experiment Video
Updated: Sep 9, 2026

Microfluidic Platform for Measuring Neutrophil Chemotaxis from Unprocessed Whole Blood
Published on: June 3, 2014
Characterization of a novel arachidonic acid-derived neutrophil chemoattractant
F J Roll1, H D Perez, C N Serhan
1Department of Medicine, University of California, San Francisco 94143.
Abstract:
The oxidation of arachidonic acid in a superoxide-generating environment results in the formation of a potent chemoattractant that appears to be identical to a chemotactic material generated by hepatocytes when they metabolize alcohol. The product was extracted, chromatographed and characterized by physical methods including GC/MS. The physical properties are consistant with the parent structure: 19-hydroperoxy, 20-hydroxyarachidic acid. This novel saturated 20 carbon product, derived from arachidonic acid by free radical-generating reactions, may play a role in the neutrophilic infiltration observed during the course of acute alcoholic hepatitis.
Related Concept Videos
Inflammation
Chemotaxis and Direction of Cell Migration
Acute Inflammation II: Cellular Phase

