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Related Experiment Videos

Ziprasidone therapy for post-traumatic stress disorder.

Zakaria Siddiqui1, William A Marcil, Subhash C Bhatia

  • 1Department of Psychiatry, Douglas County CMHC, Omaha, Neb. 68105, USA. zsiddiqui@co.douglas.ne.us

Journal of Psychiatry & Neuroscience : JPN
|December 6, 2005
PubMed
Summary

Ziprasidone therapy shows promise for chronic post-traumatic stress disorder (PTSD) in two men who previously failed other treatments. This study highlights ziprasidone

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Neuroscience

Background:

  • Chronic combat-induced post-traumatic stress disorder (PTSD) presents treatment challenges.
  • Many patients with PTSD show inadequate response to standard psychotropic agents.
  • Atypical antipsychotics have shown some efficacy in PTSD treatment.

Observation:

  • Two male patients with chronic PTSD, without active psychosis, were treated with ziprasidone.
  • Both patients had a history of insufficient response to multiple prior psychotropic medications.
  • Ziprasidone was selected for its broad neurotransmitter activity.

Findings:

  • Both patients experienced significant benefit from ziprasidone therapy.
  • Ziprasidone was effective in managing chronic PTSD symptoms in these cases.

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  • No active psychotic symptoms were present during treatment.

    • Implications:

    • This is the first report on ziprasidone's utility in PTSD pharmacotherapy.
    • Ziprasidone may be a viable treatment option for PTSD patients refractory to other agents.
    • Further research is warranted to confirm ziprasidone's efficacy and safety in PTSD.