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Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

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Ziprasidone therapy for post-traumatic stress disorder.

Zakaria Siddiqui¹, William A Marcil, Subhash C Bhatia

¹Department of Psychiatry, Douglas County CMHC, Omaha, Neb. 68105, USA. zsiddiqui@co.douglas.ne.us

Journal of Psychiatry & Neuroscience : JPN

|December 6, 2005

Summary

Ziprasidone therapy shows promise for chronic post-traumatic stress disorder (PTSD) in two men who previously failed other treatments. This study highlights ziprasidone

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Area of Science:

Psychiatry
Pharmacology
Neuroscience

Background:

Chronic combat-induced post-traumatic stress disorder (PTSD) presents treatment challenges.
Many patients with PTSD show inadequate response to standard psychotropic agents.
Atypical antipsychotics have shown some efficacy in PTSD treatment.

Observation:

Two male patients with chronic PTSD, without active psychosis, were treated with ziprasidone.
Both patients had a history of insufficient response to multiple prior psychotropic medications.
Ziprasidone was selected for its broad neurotransmitter activity.

Findings:

Both patients experienced significant benefit from ziprasidone therapy.
Ziprasidone was effective in managing chronic PTSD symptoms in these cases.
No active psychotic symptoms were present during treatment.

Implications:

This is the first report on ziprasidone's utility in PTSD pharmacotherapy.
Ziprasidone may be a viable treatment option for PTSD patients refractory to other agents.
Further research is warranted to confirm ziprasidone's efficacy and safety in PTSD.