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Angiogenesis during exercise and training.

Colin M Bloor1

  • 1Department of Pathology, University of California, San Diego, California 92037, USA. cbloor@ucsd.edu

Angiogenesis
|December 6, 2005
PubMed
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Exercise training promotes angiogenesis, the growth of new blood vessels, primarily through vascular endothelial growth factor (VEGF) and extracellular matrix changes. This review details these mechanisms and their role in exercise-induced vascular adaptations.

Area of Science:

  • Physiology
  • Molecular Biology
  • Exercise Science

Background:

  • Angiogenesis is crucial for adapting tissues to increased metabolic demands, particularly during exercise.
  • Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel formation.
  • Extracellular matrix modifications facilitate the sprouting of new blood vessels.

Purpose of the Study:

  • To review the factors initiating angiogenesis during exercise.
  • To discuss the role of extracellular matrix changes in sprouting angiogenesis.
  • To explore the regulation of VEGF production and its upregulation in response to exercise.

Main Methods:

  • Review of existing literature on angiogenesis in exercise and exercise training.
  • Analysis of studies detailing VEGF characteristics and its regulation.

Related Experiment Videos

  • Overview of extracellular matrix changes facilitating angiogenesis.
  • Inclusion of recent insights into arteriolar and larger vessel remodeling.

    • Main Results:

    • Vascular endothelial growth factor (VEGF) plays a central role in exercise-induced angiogenesis.
    • Regulation of VEGF production involves mRNA stability and transcriptional control.
    • Acute exercise upregulates VEGF, promoting capillary growth.
    • Exercise training induces extracellular matrix changes that support sprouting angiogenesis.

    Conclusions:

    • Exercise and training significantly stimulate angiogenesis through VEGF and ECM remodeling.
    • Understanding capillary development in relation to larger vessel changes in exercise training requires further investigation.