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Inhibition of transketolase and pyruvate decarboxylase by omeprazole
P F Nixon1, R J Diefenbach, R G Duggleby
1Department of Biochemistry, University of Queensland, St. Lucia, Australia.
Biochemical Pharmacology
|July 7, 1992
Abstract:
Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki value of 42 +/- 3 microM, whereas inhibition of TK was complex.