The ON/OFF-response in retinopathy of prematurity subjects with myopia

Retinopathy of prematurity (ROP) is often associated with myopia. Electrophysiological findings have shown that an imbalance of the ON- and OFF-response in subjects with ROP is associated with their refractive status. Nevertheless, the extent of these functional changes is still unclear. The aim of this study was to determine the extent of the ON- and OFF-response attenuation in ROP subjects with myopia. Fast and slow m-sequence multifocal electroretinogram were recorded on 14 eyes in 8 subjects with various degrees of myopia using the VERIS system. The spherical equivalent of refractive error ranged from -0.25 to -13.50 D. All ERG recordings were made using DTL electrodes with dilated pupils. A 19 retinally scaled hexagon stimulus was used. The findings showed that the ON- and OFF-response are reduced differently in ROP subjects with myopia. The ON-response attenuation is dependant on the severity of myopia, whereas, the OFF-response attenuation is influenced by retinal eccentricity as well as the degree of myopia. The contributions of these findings toward the understanding of retinal mechanisms controlling ocular growth need to be further explored.