Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signal transduction in natural killer cells.

A W MacFarlane1, K S Campbell

  • 1Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, 333 Cottman Ave., Philadelphia, PA 19111, USA.

Current Topics in Microbiology and Immunology
|December 7, 2005
PubMed
Summary

Natural killer (NK) cell tolerance to normal cells relies on inhibitory receptors recognizing self-MHC-I. This review details intracellular mechanisms controlling NK cell responses via signaling cross-talk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Unbiased Molecular Characterization of Peripartum Cardiomyopathy Hearts Identifies Mast Cell Chymase as a New Diagnostic Candidate.

Molecular & cellular proteomics : MCP·2026
Same author

Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure.

American journal of physiology. Heart and circulatory physiology·2022
Same author

Detection of imidacloprid and metabolites in Northern Leopard frog (Rana pipiens) brains.

The Science of the total environment·2021
Same author

KIR2DL4-HLAG interaction at human NK cell-oligodendrocyte interfaces regulates IFN-γ-mediated effects.

Molecular immunology·2018
Same author

Thermoacoustic range verification using a clinical ultrasound array provides perfectly co-registered overlay of the Bragg peak onto an ultrasound image.

Physics in medicine and biology·2016
Same author

Papular eruption in an elderly woman.

Clinical and experimental dermatology·2009

Area of Science:

  • Immunology
  • Cellular Biology
  • Molecular Signaling

Background:

  • Natural killer (NK) cells distinguish self from non-self via inhibitory receptors detecting MHC-I.
  • A balance between inhibitory and activating signals regulates NK cell function.
  • Tyrosine phosphatases recruited by inhibitory receptors counteract tyrosine kinases activated by stimulatory receptors.

Purpose of the Study:

  • To review the intracellular mechanisms governing NK cell responses.
  • To highlight signaling cross-talk between NK cell receptors.
  • To focus on signaling events at the NK immune synapse.

Main Methods:

  • Literature review of intracellular signaling pathways in NK cells.
  • Analysis of receptor-ligand interactions.

Related Experiment Videos

  • Examination of signaling cross-talk mechanisms.

    • Main Results:

    • Inhibitory receptors binding MHC-I recruit phosphatases to inhibit NK cell activation.
    • Activating receptors trigger tyrosine kinases, promoting NK cell responses.
    • The interplay between these pathways dictates NK cell cytotoxicity and cytokine production.

    Conclusions:

    • NK cell-mediated self-tolerance is a complex signaling process.
    • Understanding these mechanisms is crucial for immunotherapy and autoimmune disease research.
    • Specific receptors like NKG2D, 2B4, and KIR2DL4 play key roles in NK cell signaling dynamics.