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[Effects of arsenic on reproductive and endocrine system of female rats]
1School of Public Health, Xinjiang Medical University, Urumqi 830054, China.
Objective:
Effects of arsenic on the levels of estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) in serum of female rats, as well as histopathological changes of ovary and adrenal gland were researched.
Methods:
The hormone levels of female rats were determined by RIA exposing arsenic for 10 weeks, and histopathological examination of ovary and adrenal gland were performed with light microscope.
Results:
In spite of LH, there was no levels of three hormones (P > 0.05). However, different extents of histopathological changes in ovary and adrenal gland were found.
Conclusion:
LH is a sensitive index on hormones of female rats, but it may directly damage the reproductive system.
