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[Screening of environmental response genes related to dental fluorosis]
Guo-Qiang Hou1, Jun-Ling Liu, Yao-Yong Yu
1Henan Centers for Disease Control and Prevention, Zhengzhou 450000, China.
Objective:
To screen environmental response genes related to dental fluorosis, and to provide clues for further researches of the molecular mechanism of fluorosis.
Methods:
The leukocyte gene expression profiles of control group, high-loaded fluoride group and dental fluorosis group were tested using the gene chiR HG-U133A from Affymetrix company. The results were analyzed by bioinformatical methods.
Results:
Compared with control group, a total of 1057 genes were differentially expressed in high-loaded fluoride group. Of these, 148 were robustly up-regulated and 61 were robustly down-regulated. A total of 964 genes were differentially expressed in dental fluorosis group as compared with control group, including 71 robustly up-regulated genes and 60 robustly down-regulated genes. Compared with high-loaded fluoride group, 633 genes were identified to be differentially expressed in dental fluorosis group. Of these, the number of robustly up-regulated genes and robustly down-regulated genes were respectively 15 and 67.
Conclusion:
Multiple genes are related to fluorosis.
