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Published on: July 14, 2016
Mouse phenogenomics: the fast track to "systems metabolism"
Carmen A Argmann1, Pierre Chambon, Johan Auwerx
1Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut Nationale de la Santé et de la Recherche Médicale/Université Louis Pasteur, 67404 Illkirch, France.
Systems metabolism leverages mouse models to study complex metabolic disorders. This approach integrates genetics and physiology to understand human metabolism and disease pathogenesis.
Area of Science:
- Integrative biology
- Metabolomics
- Physiological genomics
Background:
- Genomic data is now abundant, enabling integration with physiological studies.
- The mouse serves as a key model organism for metabolic research.
Purpose of the Study:
- To review the emergence of "systems metabolism" in mammals.
- To highlight the utility of mouse models in understanding metabolic diseases.
Main Methods:
- Utilizing mouse genetics.
- Employing advanced clinical and molecular phenotyping strategies.
Main Results:
- Mouse models are instrumental in tackling complex biomedical questions.
- This approach facilitates the study of common metabolic disorder pathogenesis.
Conclusions:
- Systems metabolism in mammals, particularly using mice, is a powerful approach.
- The ultimate aim is to accurately model human metabolism and diseases.
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