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Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level
Published on: January 24, 2025
Optimal duration of PET studies with 18F-fluoroethyl-diprenorphine
Henning Boecker1, Till Sprenger, Gjermund Henriksen
1Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany. h.boecker@lrz.tu-muenchen.de
Unlabelled:
The tracer 6-O-(2-(18)F-fluoroethyl)-6-O-desmethyldiprenorphine (18F-FDPN) provides enhanced flexibility to PET studies of the opioidergic system because the label has a longer half-life than the label of 11C-diprenorphine. Here we evaluated the ideal length of PET studies with 18F-FDPN.
Methods:
18F-FDPN binding kinetics were quantified with protocols of different lengths by use of a 1-tissue or a 2-tissue compartment model for different volumes of interest. Furthermore, the effects of scanning duration were assessed by parametric analyses.
Results:
A 90-min protocol resulted in less than 10% bias in distribution volume (DV) relative to the full-length protocol. Correlation analyses of the DV estimates for the full-length protocol and the shortened protocols showed good replication of DV estimates for regions with both low and high levels of binding at schedules of up to 90 min.
Conclusion:
Data sampling in dynamic 18F-FDPN PET acquisitions should not be shorter than 90 min to maintain reliable estimates of DV.
