Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tic disorders: from pathophysiology to treatment.

Liborio Rampello1, Alessandro Alvano, Giuseppe Battaglia

  • 1Department of Neurosciences, University of Catania, Neurology, Azienda Policlinico, via S. Sofia, 78, 95123, Catania, Italy. rampello@unict.it

Journal of Neurology
|December 7, 2005
PubMed
Summary

Tic disorders, often starting in childhood and a hallmark of Tourette Syndrome (TS), are neurobehavioral conditions impacting motor and vocal behaviors. Early diagnosis and multimodal treatment, including education and medication, are crucial for managing TS and associated conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tumor Treating Fields and the Glioblastoma Microenvironment: Mechanistic Convergences with Radiotherapy.

Cancers·2026
Same author

Effects of Drugs for the Treatment of Multiple Sclerosis in Severe Acute Respiratory Syndrome Coronavirus 2 Infection on the Expression of Angiotensin-converting Enzyme 2 in vitro.

Current neuropharmacology·2026
Same author

Choroid plexus remodeling linked to impaired CSF-mediated clearance and Alzheimer's disease progression.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Endocytic turnover of endothelial cell-membrane proteins as a driver of rat blood-brain barrier specialization and dysfunction.

iScience·2026
Same author

Investigation of Magnesium Hydroxide as a Halogen-Free Fire-Retardant Filler for Advanced Polymer-Based Solutions: A Review.

Polymers·2026
Same author

Avidity-by-design: spatial control of T7 peptide presentation on polymersomes dictates blood-brain barrier transport fate.

Drug delivery and translational research·2026

Area of Science:

  • Neuroscience
  • Pediatrics
  • Genetics

Background:

  • Tic disorders are stereotypic behaviors, frequently encountered in primary care.
  • Tourette Syndrome (TS) is the most common cause of childhood-onset tics, presenting a spectrum of manifestations.
  • The pathophysiology of tics remains largely unknown, though neuroimaging implicates basal ganglia circuits and dopaminergic systems.

Purpose of the Study:

  • To provide an overview of tic disorders, focusing on Tourette Syndrome.
  • To highlight the diagnostic challenges and management strategies for TS.
  • To emphasize the importance of a multimodal treatment approach.

Main Methods:

  • Review of existing literature on tic disorders and Tourette Syndrome.
  • Discussion of neuroimaging findings related to the pathophysiology of tics.

Related Experiment Videos

  • Analysis of common comorbidities and their impact on management.

    • Main Results:

    • Tics typically begin in childhood and are characteristic of TS.
    • TS has a significant genetic component and involves specific brain circuits.
    • Comorbidities like ADHD and OCD complicate TS management.

    Conclusions:

    • Accurate diagnosis is essential for effective management of TS and related tic disorders.
    • A multimodal treatment strategy, including supportive care and pharmacotherapy, is recommended.
    • Primary care physicians play a key role in identifying and managing patients with tic disorders.