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[Relationship between serum resistin level and preeclampsia].
Dan-qing Chen1, Zheng Shi, Min-yue Dong
1The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China. chendq@zju.edu.cn
Summary
Serum resistin levels increase during normal pregnancy, peaking in the third trimester. Preeclampsia is associated with lower resistin levels compared to normal third-trimester pregnancy.
Area of Science:
- Endocrinology
- Reproductive biology
- Clinical chemistry
Context:
- Serum resistin levels are implicated in metabolic regulation.
- Pregnancy involves significant physiological changes affecting hormone and protein levels.
- Preeclampsia is a serious pregnancy complication characterized by hypertension and organ damage.
Purpose:
- To investigate the dynamic changes in serum resistin concentrations throughout normal pregnancy.
- To compare serum resistin levels between normal pregnancy and preeclampsia.
Summary:
- Serum resistin levels remained stable in non-pregnant women and during the first and second trimesters of pregnancy.
- A significant elevation in serum resistin was observed in the third trimester of normal pregnancy.
- In preeclampsia, serum resistin levels were significantly lower than in the third trimester of normal pregnancy but comparable to non-pregnant levels and earlier trimesters.
Impact:
- Findings suggest that altered resistin levels may play a role in the pathophysiology of preeclampsia.
- This research provides potential biomarkers for understanding pregnancy complications.