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[Effect of acute coronary microembolization on microvascular injury and myocardial endothelin-1 levels]
Qing-yong Zhang1, Jun-bo Ge, Jian-hua Zhu
1Department of Cardiology, The First Affiliate Hospital, College of Medicine, Zhejiang University, Hangzhou 310031, China.
Objective:
To investigate the effect of coronary microemboliation (CME) on coronary microvascular injury and myocardial endothelin-1 (ET-1) level.
Methods:
CME was induced in 10 miniswines by selective infusion of microspheres (45 microm) into left anterior descending artery (LAD). The ET-1 level in coronary sinus was measured with radioimmunoassay. The microvascular integrity indicator CFR was measured by Doppler flow wire in LAD at baseline and after infusion of microspheres.
Result:
Compared to the baseline, CFR decreased significantly with different doses of microspheres. ET-1 level increased significantly with doses of 5 x 10(4) and peaked with 10 x 10(4), and progressively decreased from doses of 12 x 10(4) to 15 x 10(4) microspheres. There was negative correlation between ET-1 and CFR (r=-0.31, P=0.02).
Conclusion:
The extent of microvascular injury is not linearly related to the extent of microembolization, but it is closely associated with myocardial ET-1 level.
Insights
Coronary microembolization causes microvascular injury, but the severity isn't directly proportional to emboli. Myocardial endothelin-1 (ET-1) levels are closely linked to microvascular damage.
Area of Science:
- Cardiovascular Research
- Vascular Biology
- Myocardial Pathophysiology
Context:
- Coronary microembolization (CME) is a recognized complication during cardiac procedures.
- Understanding CME's impact on coronary microvasculature and myocardial function is crucial for patient outcomes.
Purpose:
- To investigate the relationship between coronary microembolization (CME) and coronary microvascular injury.
- To determine the effect of CME on myocardial endothelin-1 (ET-1) levels.
Summary:
- Coronary microembolization was induced in miniswines using microspheres.
- Coronary flow reserve (CFR) significantly decreased post-embolization.
- Myocardial ET-1 levels increased with specific microsphere doses and showed a negative correlation with CFR.
Impact:
- Microvascular injury extent is not linearly related to embolization extent.
- Myocardial ET-1 levels are closely associated with the degree of microvascular injury.
- Findings suggest ET-1 as a potential biomarker for CME-induced microvascular damage.
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