Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel multiwavelength microscopic scanner for mouse imaging.

Herlen Alencar1, Umar Mahmood, Yoshihiro Kawano

  • 1Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

Neoplasia (New York, N.Y.)
|December 8, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coexisting intrarenal arteriovenous and caliceovenous fistulae after percutaneous nephrolithotomy: Case report and literature review.

Interventional medicine & applied science·2013
Same author

Modality-specific occult intrarenal pseudoaneurysm in a renal allograft and the legacy of catheter angiography.

Annals of vascular surgery·2013
Same author

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy.

Nature medicine·2012
Same author

Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cells.

Journal of the American Chemical Society·2012
Same author

Improved intravital microscopy via synchronization of respiration and holder stabilization.

Journal of biomedical optics·2012
Same author

Modeling biological activities of nanoparticles.

Nano letters·2012
Same journal

The importance of HPV testing in oropharyngeal cancer in two US populations.

Neoplasia (New York, N.Y.)·2026
Same journal

Multi-omics characterization of radiation-induced cerebellar remodeling and tumorigenic transcriptional programs.

Neoplasia (New York, N.Y.)·2026
Same journal

Deep learning of pretreatment ascites cytopathology for platinum-resistance risk stratification in advanced epithelial ovarian cancer.

Neoplasia (New York, N.Y.)·2026
Same journal

The benefit of deep genomic testing for asymptomatic high-risk individuals undergoing surveillance for pancreatic adenocarcinoma: European registry for hereditary pancreatic diseases (EUROPAC-PLUS).

Neoplasia (New York, N.Y.)·2026
Same journal

Heterogeneous SPP1-expressing esophageal cancer cells license immunotherapy resistance by organizing an immunosuppressive niche.

Neoplasia (New York, N.Y.)·2026
Same journal

Fusion gene heterogeneity and kinase enrichment in high-grade serous carcinomas.

Neoplasia (New York, N.Y.)·2026
See all related articles

A novel near-infrared laser scanning microscope enables real-time, in vivo imaging of molecular targets within organs. This breakthrough system offers high resolution for advanced cellular biology and cancer imaging research.

Area of Science:

  • Biomedical Optics
  • In Vivo Imaging
  • Microscopy

Background:

  • Understanding complex biology requires real-time in vivo imaging at subcellular resolution.
  • Traditional microscopy methods (confocal, multiphoton) are limited by bulky optics and external organ access.

Purpose of the Study:

  • To develop and validate a novel near-infrared laser scanning microscope system.
  • To overcome limitations of existing microscopy for deep tissue imaging in vivo.

Main Methods:

  • Development of a compact near-infrared laser scanning microscope with novel optics.
  • Utilized a 1.3-mm-diameter stick objective for deep imaging (up to 500 microm).
  • Combined the system with novel far-red imaging probes.

Main Results:

Related Experiment Videos

  • Achieved high spatial, temporal, and multiwavelength resolutions.
  • Demonstrated imaging capabilities in virtually any internal organ via keyhole surgical access.
  • Successfully imaged cellular details and disease processes in vivo.

Conclusions:

  • The developed near-infrared microscope system offers significant advantages for in vivo imaging.
  • Its compact design and deep imaging capabilities are valuable for studying internal organs.
  • This technology, with far-red probes, is promising for in vivo cancer imaging.