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Updated: Aug 14, 2026
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Impression Cytology of the Lid Wiper Area
Published on: August 9, 2016
Subconjunctival cyst-like formations following impression cytology
Sruthi Srinivasan1, Elizabeth Joyce, Lyndon W Jones
1Centre for Contact Lens Research, School of Optometry, University of Waterloo, 200, University Avenue West, Waterloo, Ont., Canada N2L 3G1. s2sriniv@uwaterloo.ca
Summary
Conjunctival Impression Cytology (CIC) can cause temporary bubble formation and redness under the conjunctiva. This unusual adverse event is typically mild and resolves within an hour.
Area of Science:
- Ophthalmology
- Ocular Surface Disease
Background:
- Conjunctival Impression Cytology (CIC) is a valuable diagnostic technique for evaluating the ocular surface.
- Minimally invasive procedures like CIC require careful execution to prevent adverse events.
Observation:
- A case report details an unusual adverse event following CIC in a healthy 54-year-old female.
- The procedure involved a 10 mm Millipore membrane applied to the bulbar conjunctiva under topical anesthesia.
Findings:
- Post-procedure, the patient experienced significant bulbar conjunctival hyperemia and reported "bubbles" or cystic formations under the conjunctiva.
- These conjunctival cysts, though visually striking, were asymptomatic and resolved completely within one hour.
Implications:
- This case highlights a rare, transient complication of CIC, characterized by subconjunctival bubble formation.
- Ophthalmologists should be aware of this potential, albeit benign, adverse event and counsel patients on possible short-term redness and discomfort.
