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Related Experiment Videos

Exploring soft matter: liposomal vesicles and their tethers.

Behrooz Nasseri1, Alessandro Fasciolo

  • 1Centre for Drug Delivery Research, School of Pharmacy, University of London, UK. behrooz.nasseri@ulsop.ac.uk

Journal of Drug Targeting
|December 8, 2005
PubMed
Summary

Soft matter vesicles can form self-healing tethers for micro-transport. These channels transport particles and liposomes, enabling vesicle-to-vesicle component transfer.

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Area of Science:

  • Soft Matter Physics
  • Materials Science
  • Biophysics

Background:

  • Vesicular systems exhibit malleability, enabling mechanical manipulation into functional structures.
  • Elastic membrane properties of vesicles are key for fabricating micro-scaled transport machinery.
  • Research explores self-healing and structural capabilities of multilamellar liposomes.

Purpose of the Study:

  • To investigate the self-healing properties of multilamellar liposomes.
  • To demonstrate the formation and application of tethers from liposome bilayers.
  • To establish a liposome-based system for micro-component transport.

Main Methods:

  • Mechanical manipulation of vesicular systems.
  • Inducing self-healing in liposomes after inner core removal.

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  • Fabricating tether networks from liposome outer bilayers.
  • Utilizing photo-enhanced imaging to visualize internal channels within tethers.
  • Employing tethers as transport conduits for microspheres and liposomes.

    • Main Results:

    • Demonstrated self-healing of multilamellar liposomes.
    • Observed formation of complex tether networks from liposome bilayers.
    • Revealed narrow channels within tethers via photo-enhanced imaging.
    • Successfully transported polystyrene microspheres and larger liposomes through tether channels at speeds up to 2 microm s(-1).
    • Showcased transport of components between connected vesicle entities via fusion or tether networks.

    Conclusions:

    • Liposome-derived tethers serve as functional micro-transport conduits.
    • The system facilitates controlled transport of various micro-objects.
    • Multi-compartment liposomal systems connected by tethers offer a novel platform for inter-vesicle transport.