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Cardiac effects of a single course of antenatal betamethasone in preterm infants
1Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. vuralm@istanbul.edu.tr
Insights
A single course of antenatal betamethasone did not alter cardiac measurements or systolic function in premature infants. This study found no significant differences in cardiac development between infants exposed and unexposed to antenatal steroids.
Area of Science:
- Neonatal Cardiology
- Perinatology
- Pediatric Echocardiography
Background:
- Antenatal corticosteroids, like betamethasone, are administered to pregnant individuals to promote fetal lung maturity.
- The impact of antenatal betamethasone on the developing cardiovascular system of premature infants requires further investigation.
Purpose of the Study:
- To evaluate the effects of a single course of antenatal betamethasone on cardiac dimensions and systolic function in preterm neonates.
- To assess cardiac measurements and systolic function in premature infants based on antenatal betamethasone exposure.
Main Methods:
- Seventy-six premature infants (25-33 weeks gestational age) were studied.
- Echocardiographic scans were performed at birth, and at 1 and 3 weeks postpartum.
- Cardiac measurements including interventricular septum, posterior wall thickness, and ventricular dimensions were analyzed.
Main Results:
- No significant differences were observed in cardiac measurements (IVS, LVPW, LVED, LVES, AO, LA) between betamethasone-exposed and non-exposed infants.
- Systolic function, assessed by fractional shortening, showed no significant variation between groups.
- The interventricular septum to left ventricular posterior wall ratio (IVS/LVPW) did not differ, indicating no asymmetrical septal hypertrophy.
Conclusions:
- A single course of antenatal betamethasone does not adversely affect cardiac wall thickness or systolic function in premature infants.
- The findings suggest that antenatal betamethasone is safe concerning cardiac development in preterm neonates.
Aim:
To show the effects of a single course of antenatal betamethasone on cardiac measurements and systolic functions in premature newborn infants.
Methods:
Seventy six newborn infants with a gestational age of 25-33 weeks were included in the study. They were first classified according to their gestational age: 25-29 weeks (n = 28) and 30-33 weeks (n = 48). They were then reclassified as betamethasone positive (mother received one course of betamethasone) or betamethasone negative (mother did not receive any antenatal glucocorticoid treatment). Cross sectional M mode echocardiographic scans were performed during the first three postnatal days and at the end of the first and third weeks. Left interventricular septum (IVS), left ventricular posterior wall (LVPW), left ventricular end diastolic (LVED), and left ventricular end systolic (LVES) dimensions, aortic root (AO), and left atrial diameters (LAs) were measured. The IVS to LVPW ratio was calculated to identify asymmetrical septal hypertrophy.
Results:
In neither group was any statistically significant difference noted in IVS, LVED, LVES, LVPW, LA, and AO measurements during the three cardiac ultrasonography scans. Systolic function, as assessed by fractional shortening, was not significantly different in infants who received betamethasone antenatally, in either age group. There was no difference in the IVS/LVPW ratios between those who received antenatal steroid and those who did not for the 25-29 week and 30-33 week groups during these three consecutive scans.
Conclusion:
One course of antenatal betamethasone did not affect the cardiac wall thicknesses and systolic function in premature infants.
