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Related Experiment Videos

Synthetic hydroxyapatite-based integrated orbital implants: a human pilot trial.

Biswanath Kundu1, Mithlesh K Sinha, Santanu Mitra

  • 1Central Glass and Ceramic Research Institute, Kolkata, India.

Indian Journal of Ophthalmology
|December 8, 2005
PubMed
Summary

Synthetic hydroxyapatite (HAp) orbital implants offer safe and effective volume replacement after eye surgery. These porous implants integrate with prosthetic shells, enhancing cosmetic satisfaction and eye movement.

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Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Orbital implants are crucial for cosmesis and function post-enucleation/evisceration.
  • Porous hydroxyapatite (HAp) implants, derived from natural sources or synthetically, are increasingly used.
  • Synthetic HAp implants offer direct integration with prosthetic shells, improving motility.

Purpose of the Study:

  • To evaluate the efficacy of two synthetic HAp orbital implant models.
  • Assess implants with 75% porosity and 100-300 mm pore sizes.
  • Investigate clinical safety and cosmetic outcomes.

Main Methods:

  • Synthetic HAp powders prepared via a novel wet chemical route.
  • Two implant models developed for evisceration/enucleation, implanted in 25 patients.

Related Experiment Videos

  • Postoperative assessment included volume replacement, socket health, MRI for vascularization, motility, and cosmetic results.

    • Main Results:

    • No significant complications over 2.5 years; minor exposures/thinning managed successfully.
    • 14/25 patients achieved very good prosthesis motility (>20 degrees); 11/25 had fair motility (10-20 degrees).
    • Very good volume replacement in 21/25 patients; all reported cosmetic satisfaction.

    Conclusions:

    • Modified synthetic HAp-based integrated orbital implants are clinically safe.
    • These implants provide cosmetically acceptable results.
    • The study supports the use of these advanced synthetic HAp implants in ocular prosthetics.