Related Experiment Videos
Sjögren's syndrome with hydronephrosis caused by pseudolymphoma
T Yuhara1, M Sakauchi, T Akama
1Department of Internal Medicine, University of Tsukuba, Japan.
Internal Medicine (Tokyo, Japan)
|April 1, 1992
Summary
Sjögren's syndrome can cause rare ureteral obstruction due to lymphoid hyperplasia. This condition, presenting as hydronephrosis, is treatable with low-dose prednisolone, leading to symptom reversal.
Area of Science:
- Nephrology
- Urology
- Rheumatology
Background:
- Sjögren's syndrome is a chronic autoimmune disease primarily affecting exocrine glands.
- Complications can extend beyond typical sicca symptoms, impacting various organ systems.
- Ureteral obstruction is an uncommon manifestation, necessitating thorough investigation.
Observation:
- A 67-year-old female patient with Sjögren's syndrome presented with left hydronephrosis and ureteral stenosis.
- Diagnostic laparotomy revealed a nodule at the left ureteropelvic junction.
- Histopathology confirmed lymphoid hyperplasia within the ureteral wall, consistent with pseudolymphoma.
Findings:
- The patient was treated with low-dose prednisolone.
- Significant improvement in hydronephrosis and ureteral pseudolymphoma was observed within months.
- This suggests a responsive inflammatory process.
Implications:
- Hydronephrosis due to ureteral pseudolymphoma is a rare but reversible complication of Sjögren's syndrome.
- Early diagnosis and immunosuppressive therapy can prevent irreversible renal damage.
- Highlights the importance of considering extraglandular manifestations in Sjögren's syndrome management.