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Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide
Seong L Khaw1, Peter A Downie, Keith D Waters
1Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia.
Abstract:
Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. We report a series of children with malignant disease, who developed such reactions following mesna administration and discuss possible mechanisms and management issues.
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