Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The multi-level Meta analysis model combining individual level data with aggregative level data].

Cai-Rong Zhu1, Zhong-Hua Liu, Ke-Hong Sun

  • 1Department of Health Statistics, West China School of Public Health, Sichuan University, Chengdu 610041, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|December 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic syndrome worsens perioperative and oncological outcomes in patients with pancreatic ductal adenocarcinoma after R0 resection: A multicenter propensity score-matched study.

Hepatobiliary & pancreatic diseases international : HBPD INT·2026
Same author

Protective role of alpha-linolenic acid against ATGL inhibition-induced lipid accumulation and developmental defects in porcine oocytes.

Theriogenology·2026
Same author

PEG-mediated transformation: a tool for random integration or targeted gene replacement in <i>Colletotrichum camelliae</i>.

Frontiers in microbiology·2026
Same author

Development and external validation of an interpretable multimodal deep learning model for 5-year mortality in high-risk stage ii colorectal cancer.

International journal of colorectal disease·2026
Same author

Different doses of vitamin A supplementation as adjuvant treatment for pneumonia in children: a network meta-analysis of randomized controlled trials.

European journal of pediatrics·2026
Same author

The AP2/ERF transcription factor CsRAV1 represses CsGL2 to regulate the trichome development of tea plants.

Plant physiology and biochemistry : PPB·2026

This study introduces a multi-level meta-analysis model combining individual and aggregated data for medical research. This approach enhances data utilization and improves the accuracy of results, particularly in drug efficacy studies.

Area of Science:

  • Medical Statistics
  • Pharmacological Research
  • Data Science

Background:

  • Meta-analysis is crucial for synthesizing research findings.
  • Integrating individual participant data (IPD) with aggregate data (AD) offers potential advantages.
  • Challenges exist in combining diverse data sources effectively.

Purpose of the Study:

  • To develop and demonstrate a multi-level meta-analysis model.
  • To combine individual-level clinical trial data with aggregate-level literature data.
  • To apply this model to assess the efficacy of roglizatone.

Main Methods:

  • A multi-level meta-analysis model was constructed.
  • Individual data from roglizatone natrium trials were combined with aggregate data from literature.

Related Experiment Videos

  • The model assessed the difference in decreased hemoglobin A1c between roglizatone and control groups.

    • Main Results:

    • The study analyzed data with a baseline hemoglobin A1c of 9% and a roglizatone dose of 4 mg/day.
    • The average reduction in hemoglobin A1c with roglizatone was 0.464% (95% CI: 0.168%–0.760%).
    • This demonstrates the model's ability to yield precise effect estimates.

    Conclusions:

    • The multi-level meta-analysis model effectively utilizes available data resources.
    • Combining individual and aggregate data leads to more accurate and reliable study outcomes.
    • This integrated approach is valuable for medical research when individual data is accessible.