Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A method for delineating structurally homogeneous regions in protein sequences.

C Chappey1, S Hazout

  • 1Unité de Recherches Biomathématiques et Biostatistiques, INSERM U 263, Université Paris 7, France.

Computer Applications in the Biosciences : CABIOS
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Antenatal diagnosis of an umbilical cord hemangioma].

Gynecologie, obstetrique, fertilite & senologie·2018
Same author

Sulfonic Membrane Sorption and Permeation Properties: Complementary Approaches to Select a Membrane for Pervaporation.

The journal of physical chemistry. B·2017
Same author

Layered Poly(ethylene-co-vinyl acetate)/Poly(ethylene-co-vinyl alcohol) Membranes with Enhanced Water Separation Selectivity and Performance.

ACS applied materials & interfaces·2017
Same author

A part-randomized study of intravenous oseltamivir in adolescents and adults.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2015
Same author

Extraction of melodies in behavioural sequences.

Behavioural processes·2014
Same author

Transport mechanisms of small molecules through polyamide 12/montmorillonite nanocomposites.

The journal of physical chemistry. B·2010
Same journal

DCA: an efficient implementation of the divide-and-conquer approach to simultaneous multiple sequence alignment.

Computer applications in the biosciences : CABIOS·1998
Same journal

Two applications to facilitate the viewing of database search result files on the Macintosh.

Computer applications in the biosciences : CABIOS·1998
Same journal

BioWish: a molecular biology command extension to Tcl/Tk.

Computer applications in the biosciences : CABIOS·1998
Same journal

The Sequence Alerting Server--a new WEB server.

Computer applications in the biosciences : CABIOS·1998
Same journal

A software tool for the analysis of mass spectrometric disulfide mapping experiments.

Computer applications in the biosciences : CABIOS·1998
Same journal

SAMBA: hardware accelerator for biological sequence comparison.

Computer applications in the biosciences : CABIOS·1998
See all related articles

This study introduces a novel algorithm to identify homogeneous regions in protein sequences based on shared features. The method segments sequences using customizable parameters, aiding in analyzing protein structures and functions.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Protein Sequence Analysis

Background:

  • Homogeneous regions in protein sequences are contiguous segments sharing physico-chemical, structural, or mutational features.
  • Identifying these regions is crucial for understanding protein function and evolution.
  • Previous methods may lack flexibility in defining region characteristics.

Purpose of the Study:

  • To present a new algorithm for identifying homogeneous regions within protein sequences.
  • To enable sequence segmentation based on user-defined parameters for region homogeneity and site neighborhood.
  • To apply the method to HIV-1 envelope proteins for analyzing hydrophobicity and variability.

Main Methods:

  • Developed a segmentation algorithm that optimizes a criterion based on two user-defined parameters: 'homogenizing degree' and 'site neighbourhood' size.

Related Experiment Videos

  • The algorithm processes sequence profiles representing biological information (e.g., hydrophobicity, variability).
  • Applied the method to envelope proteins of human immunodeficiency virus type 1 (HIV-1).

    • Main Results:

    • Successfully identified homogeneous regions in HIV-1 envelope proteins based on hydrophobicity profiles.
    • Delineated variable and conserved regions within the same protein using variability profiles.
    • The algorithm's flexibility allows for tailored analysis of protein sequence characteristics.

    Conclusions:

    • The presented method provides an effective approach for identifying and characterizing homogeneous regions in protein sequences.
    • The algorithm's customizable parameters enhance its applicability to diverse biological datasets, such as viral proteins.
    • This tool aids in the detailed analysis of protein structure-function relationships and evolutionary patterns.