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Multiple plaques on the back: S-100 negative benign granular cell tumor
Ozer Arican1, Harun Ciralik, Sezai Sasmaz
1Department of Dermatology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Turkey.
The Journal of Dermatology
|December 13, 2005
Summary
A rare granular cell tumor case presented in an 18-year-old female. This S-100 negative tumor appeared as multiple asymptomatic lesions, challenging typical diagnostic markers.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Granular cell tumors (GCTs) are rare neoplasms, typically originating from Schwann cells.
- They commonly present as gradually developing nodular lesions, often diagnosed in middle-aged women and Black individuals.
- Malignancy potential is low (1-3%), with multifocal occurrences in 10-25% of cases.
Observation:
- This report details an unusual case of a benign granular cell tumor in an 18-year-old female.
- The tumor presented as multiple, asymptomatic, light brown plaques and maculopapular lesions on the back.
- Lesion diameters ranged from 0.5-4 cm, with gradual growth over nine years.
Findings:
- Unlike typical GCTs, this tumor was negative for S-100 protein, a common diagnostic marker.
- Histopathological examination of biopsies confirmed the diagnosis of benign granular cell tumor.
- The multifocal nature and S-100 negativity represent atypical features for this rare tumor.
Implications:
- This case highlights the diagnostic challenges posed by atypical granular cell tumors.
- It underscores the importance of considering S-100 negativity in the differential diagnosis of GCTs.
- Further research may elucidate the specific cellular origins and molecular pathways in S-100 negative GCTs.