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Related Experiment Videos

Liver support systems: promise and reality.

Alan J Wigg1, Robert T Padbury

  • 1South Australian Liver Transplantation Unit, Flinders Medical Center, Adelaide, South Australia, Australia. alan.wigg@flinders.edu.au

Journal of Gastroenterology and Hepatology
|December 13, 2005
PubMed
Summary

Extracorporeal liver support systems show promise but lack robust clinical evidence. Current systems like MARS and HepatAssist are not recommended for routine use due to insufficient data in human liver failure.

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Area of Science:

  • Hepatology and Artificial Organ Development

Background:

  • Extracorporeal liver support systems (ELSS) have been researched for 50 years.
  • Both biological and non-biological systems exist, but clinical data is limited.
  • Human liver failure necessitates effective support solutions.

Purpose of the Study:

  • To review existing data on ELSS, focusing on MARS and HepatAssist.
  • To discuss challenges in ELSS development.
  • To assess the current evidence base for clinical application.

Main Methods:

  • Literature review of randomized controlled trials and existing data.
  • Emphasis on prominent systems like MARS and HepatAssist.
  • Analysis of developmental challenges and functional requirements.

Main Results:

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  • A significant lack of high-quality randomized controlled data exists for human liver failure.
  • Current front-runner systems (MARS, HepatAssist) lack sufficient evidence for routine clinical recommendation.
  • Understanding of critical liver support functions is insufficient for rational system design.

Conclusions:

  • ELSS show promise in animal studies but lack strong clinical evidence in humans.
  • Routine clinical use of current ELSS is not supported by adequate data.
  • Further research is needed to understand critical functions for improved ELSS design.