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Published on: April 21, 2014
Molecular/genetic determinants of repolarization and their modification by environmental stress
1Department of Pharmacology, Center for Molecular Therapeutics, College of Physicians & Surgeons of Columbia University, New York, NY 10032, USA. mrr1@columbia.edu
Abstract:
Although a variety of factors, inherited or environmental, can influence expression of ion channel proteins to impact on repolarization, that environment can affect genetic determinants of repolarization for intervals of varying duration is a concept that is not as generally appreciated as it should be. In the following pages we review the molecular/genetic determinants of cardiac repolarization and summarize how pathologic events and environmental intrusions can affect these determinants. Understanding the chains of events involved should yield insights into both the causes and potential avenues of treatment for abnormalities of repolarization.
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