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Published on: May 14, 2013

Impact of pathogen burden on in-stent restenosis in patients after coronary stent implantation

Yu-hong Niu1, Jun-bo Ge, Cong-feng Xu

  • 1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Chinese Medical Journal
|December 13, 2005
PubMed

Insights

Previous infections with common pathogens do not increase the risk of in-stent restenosis after coronary stent implantation. The number of infections did not correlate with restenosis rates in patients undergoing this procedure.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Research

Background:

  • Infectious pathogens are sometimes found in coronary artery disease patients, but their role is unclear.
  • The relationship between pathogen burden and coronary artery disease development requires further investigation.

Purpose of the Study:

  • To investigate the association between the number of infectious pathogens and the incidence of in-stent restenosis following coronary stent implantation.

Main Methods:

  • 181 patients were assessed for antibodies to Chlamydia pneumoniae, cytomegalovirus, Helicobacter pylori, herpes simplex viruses 1 & 2, and hepatitis B virus antigen.
  • Coronary angiography was performed pre-procedure, immediately post-procedure, and at 6-month follow-up.

Main Results:

  • The 6-month restenosis rate was comparable between patients with low pathogen burden (33.3%) and high pathogen burden (29.1%).

Conclusions:

  • Prior infections with specific pathogens do not appear to influence the occurrence of restenosis after coronary stent implantation.
Abstract

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