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Updated: Aug 11, 2026

In vitro Investigation of the MexAB Efflux Pump From Pseudomonas aeruginosa
Published on: February 17, 2014
The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux
Christopher L Reyes1, Andrew Ward, Jodie Yu
1Department of Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, CB105, La Jolla, CA 92137, USA.
Abstract:
ATP-binding cassette (ABC) transporters are integral membrane proteins that couple ATP hydrolysis to the transport of various molecules across cellular membranes. Found in both prokaryotes and eukaryotes, a sub-group of these transporters are involved in the efflux of hydrophobic drugs and lipids, causing anti-microbial and chemotherapeutic multidrug resistance. In this review, we examine recent structural and functional analysis of the ABC transporter MsbA and implications on the mechanism of multidrug efflux.
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