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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

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Ascorbic acid for the common cold. A prophylactic and therapeutic trial.

T R Karlowski, T C Chalmers, L D Frenkel

|March 10, 1975

Summary

Ascorbic acid (vitamin C) showed minimal impact on common cold duration and severity in a nine-month study. The observed effects may have been influenced by participants breaking the double-blind protocol.

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Published on: January 2, 2017

Area of Science:

Nutrition Science
Public Health
Clinical Research

Background:

The common cold remains a prevalent illness with significant impact on productivity.
Ascorbic acid (vitamin C) is widely believed to prevent or treat colds, though scientific evidence is debated.

Purpose of the Study:

To investigate the efficacy of high-dose ascorbic acid supplementation in reducing the duration and severity of common colds.
To assess the impact of ascorbic acid on cold incidence and dropout rates in a controlled trial.

Main Methods:

A nine-month, double-blind, placebo-controlled study involving 311 National Institutes of Health employees.
Participants received 1 gm of ascorbic acid or lactose placebo thrice daily, with an additional 3 gm daily at cold onset.
Dropout rates were monitored, with dropouts defined as missing at least one month of study medication.

Main Results:

Only 190 volunteers completed the study; dropout rates were higher in the placebo group (44%) than the ascorbic acid group (34%).
Ascorbic acid demonstrated a minor influence, at best, on cold duration and severity.
The observed effects could potentially be attributed to a breach in the double-blind condition.

Conclusions:

High-dose ascorbic acid supplementation appears to have a limited effect on common cold symptoms.
Further research is needed to confirm these findings and explore potential confounding factors like adherence and blinding integrity.