Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

c-Yes response to growth factor activation.

David A Clump1, Ihtishaam H Qazi, Marius Sudol

  • 1Department of Microbiology, Immunology, and Cell Biology, The Mary Babb Randolph Cancer Center and the West Virginia University, Morgantown, WV 26506-9300, USA.

Growth Factors (Chur, Switzerland)
|December 13, 2005
PubMed
Summary

The Src family kinases, c-Yes and c-Src, have distinct roles in cell signaling and physiological functions. c-Yes is crucial for tight junction formation and transcytosis, while c-Src impacts osteoclast function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A systematic review of artificial intelligence in radiotherapy associated cardiovascular toxicity.

Cardio-oncology (London, England)·2026
Same author

Transient ATR inhibition following ionizing radiation enhances immune-mediated antitumor response and survival.

bioRxiv : the preprint server for biology·2026
Same author

A Case for Caution in a New Era of Managing Patients with Locally Advanced Non-Small Cell Lung Cancer: Fatal Bronchial-Esophageal Fistula After Neoadjuvant Chemo-Immunotherapy Followed by Definitive Chemoradiation Therapy.

Practical radiation oncology·2025
Same author

Artificial Intelligence and Machine Learning in Sexual Health and Dysfunction Across the Cancer Care Continuum: A Systematic Review.

Cancers·2025
Same author

Detecting Extranodal Extension in HPV-Related Oropharyngeal Cancer via Machine Learning.

The Laryngoscope·2025
Same author

Randomized Phase II Study of Concurrent Versus Sequential Pembrolizumab in Combination With Chemoradiation in Locally Advanced Head and Neck Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2025

Area of Science:

  • Cellular signaling and molecular biology
  • Biochemistry and kinase function
  • Physiology and disease

Background:

  • Transmembrane receptors mediate cell communication, influencing vital cellular processes.
  • Src family kinases, including c-Src and c-Yes, are key regulators of this signaling.
  • Despite structural similarities, c-Yes and c-Src exhibit distinct functional roles.

Purpose of the Study:

  • To review the specific receptor signaling pathways that influence c-Yes activity.
  • To elucidate how these interactions impact the known physiological roles of c-Yes.
  • To differentiate the signaling mechanisms of c-Yes and c-Src.

Main Methods:

  • Analysis of tight junction formation to differentiate c-Yes and c-Src signaling.
  • Investigation of pp62c-Yes and c-src knockout mouse models.

Related Experiment Videos

  • Review of receptor tyrosine kinase interactions with Src family kinases.

    • Main Results:

    • c-Yes promotes tight junction formation via occludin phosphorylation; c-Src downregulates it.
    • c-yes-/- mice show impaired transcytosis of pIgA.
    • c-src-/- mice exhibit osteoclast dysfunction and reduced bone resorption.

    Conclusions:

    • c-Yes and c-Src possess unique functions in cellular processes and physiology.
    • Specific receptor signaling pathways differentially regulate c-Yes activity.
    • Understanding these distinct roles is crucial for deciphering complex cellular communication networks.