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Updated: May 7, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
Infliximab for induction and maintenance therapy for ulcerative colitis
Paul Rutgeerts1, William J Sandborn, Brian G Feagan
1University Hospital Gasthuisberg, Leuven, Belgium. paul.rutgeerts@uz.kuleuven.ac.be
Infliximab significantly improved clinical response in ulcerative colitis patients compared to placebo. This study demonstrates infliximab
Area of Science:
- Gastroenterology
- Immunology
- Pharmacology
Background:
- Infliximab, a tumor necrosis factor alpha inhibitor, is approved for Crohn's disease.
- Its efficacy in ulcerative colitis required further investigation.
Purpose of the Study:
- To evaluate the efficacy of infliximab in treating moderate-to-severe active ulcerative colitis.
- To assess infliximab's induction and maintenance therapy effects.
Main Methods:
- Two randomized, double-blind, placebo-controlled trials (ACT 1 and ACT 2) were conducted.
- 364 patients received placebo or infliximab (5 or 10 mg/kg) intravenously at specified intervals.
- Patients were followed for up to 54 weeks.
Main Results:
- At week 8, clinical response rates were significantly higher in infliximab groups (61-69%) versus placebo (29-37%, P<0.001).
- Higher response rates were observed at weeks 30 and 54 in infliximab-treated patients.
- Clinical response was defined by significant decreases in Mayo score and rectal bleeding subscore.
Conclusions:
- Infliximab treatment led to a greater clinical response in patients with moderate-to-severe ulcerative colitis compared to placebo.
- The observed efficacy supports infliximab's role in ulcerative colitis management.
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