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Menstruation-free interval and ongoing pregnancy in IVF using GnRH antagonists
Efstratios M Kolibianakis1, Evangelos G Papanikolaou, Michel Camus
1Unit for Human Reproduction, Aristotle University, Thessaloniki, Greece. Stratis.Kolibianakis@otenet.gr
Human Reproduction (Oxford, England)
|December 13, 2005
Summary
The time from menstruation to hCG administration impacts IVF success. A longer menstruation-free interval is associated with a lower chance of ongoing pregnancy in women undergoing IVF.
Area of Science:
- Reproductive Endocrinology
- In Vitro Fertilization (IVF)
Background:
- The menstruation-free interval (MFI) is a factor in IVF outcomes.
- Understanding MFI's impact is crucial for optimizing treatment protocols.
Purpose of the Study:
- To prospectively assess the association between MFI and ongoing pregnancy rates in IVF patients.
- To determine if MFI predicts IVF success.
Main Methods:
- 90 patients received recombinant FSH (rFSH) and GnRH antagonist.
- Oocyte maturation was triggered with hCG when three follicles ≥17 mm were observed.
- Single embryo transfer was performed in 64.6% of eligible patients.
Main Results:
- The ongoing pregnancy rate per embryo transfer was 18.3%.
- The MFI significantly predicted ongoing pregnancy probability (OR 0.70; 95% CI: 0.54-0.92).
- Logistic regression controlled for female age and LH levels.
Conclusions:
- A longer MFI correlates with a reduced likelihood of ongoing pregnancy in IVF.
- This finding is relevant for patients stimulated with rFSH and GnRH antagonist.
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