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Updated: Aug 14, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Genomics of the future: identification of quantitative trait loci in the mouse
Lorraine Flaherty1, Bruce Herron, Derek Symula
1Genomics Institute, Wadsworth Center, Troy, New York 12180, USA. flaherty@wadsworth.org
Abstract:
Positional cloning of quantitative trait loci in rodents is a common approach to identify genes involved in complex phenotypes, including genes important to human disease. However, cloning the causative genes has proved to be more difficult than determining their positions. New tools such as genomic sequence, clone libraries, and new genomic-based methods offer new approaches to identify these genes. Here we review how these new tools and approaches will improve our ability to discover the genes important in complex traits.
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