Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel quantitative phenotypes of exercise training in mouse models.

J P De Bono1, D Adlam, D J Paterson

  • 1Department of Cardiovascular Medicine, University of Oxford, Level 5, John Radcliffe Hospital, Oxford OX3 9DU, UK.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|December 13, 2005
PubMed
Summary

Mice run at a preferred cruising speed during the night. This study introduces a new system to precisely measure mouse exercise, revealing sex differences and improving exercise phenotyping in genetic models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pure CO<sub>2</sub> and impure CO<sub>2</sub>-SO<sub>2</sub>-NO-O<sub>2</sub> reactions with carbon storage site underlying seals: Coaly mudstones and carbonate cemented sandstones.

The Science of the total environment·2025
Same author

Neurocardiology: translational advancements and potential.

The Journal of physiology·2024
Same author

Geographical Variation in Underlying Social Deprivation, Cardiovascular and Other Comorbidities in Patients with Potentially Curable Cancers in England: Results from a National Registry Dataset Analysis.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023
Same author

Psychological and clinical characteristics of female patients with spontaneous coronary artery dissection.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2020
Same author

Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.

Digestive diseases and sciences·2019
Same author

Neurocardiac regulation: from cardiac mechanisms to novel therapeutic approaches.

The Journal of physiology·2018

Area of Science:

  • Physiology
  • Exercise Science
  • Animal Models

Background:

  • Physical exercise benefits numerous human diseases.
  • Mouse models are crucial for understanding exercise's molecular mechanisms.
  • Normal mouse exercise physiology is poorly understood.

Purpose of the Study:

  • To develop a novel system for precise measurement of mouse exercise.
  • To characterize normal voluntary wheel-running behavior in mice.
  • To identify parameters for improved exercise phenotyping in genetic models.

Main Methods:

  • Development of a computerized voluntary wheel-running system.
  • Recording and analysis of individual wheel rotations.
  • Characterization of running speed, distance, and bout patterns.

Related Experiment Videos

Main Results:

  • C57BL/6 mice exhibit nocturnal running in bouts at a preferred 'cruising speed'.
  • Most running occurs near cruising speed, higher than simple odometer averages.
  • Exercise training alters running parameters, with significant sex differences observed.

Conclusions:

  • The novel system provides accurate, physiological measures of mouse exercise.
  • Understanding normal running patterns is vital for interpreting exercise studies.
  • This system enhances exercise training's utility as a phenotyping tool for genetic mouse models.