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Conjugated linoleic acid impairs endothelial function.

Justin S W Taylor1, Simon R P Williams, Rhian Rhys

  • 1Morriston Hospital, Swansea, UK. jswt@totalise.co.uk

Arteriosclerosis, Thrombosis, and Vascular Biology
|December 13, 2005
PubMed
Summary
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Conjugated linoleic acid (CLA) supplementation did not significantly reduce body mass index or total body fat. However, it worsened endothelial function and increased oxidative stress, suggesting it is not recommended for weight loss.

Area of Science:

  • Nutrition Science
  • Cardiovascular Health
  • Metabolic Research

Background:

  • Conjugated linoleic acid (CLA) is a popular dietary supplement investigated for its potential effects on body composition and cardiovascular health.
  • Previous research suggests CLA may influence adiposity, but its impact on endothelial function and cardiovascular risk markers requires further elucidation.

Purpose of the Study:

  • To evaluate the efficacy of conjugated linoleic acid (CLA) isomeric mixture supplementation on body mass index (BMI), body fat distribution, endothelial function, and cardiovascular risk markers.
  • To assess the safety and potential adverse effects of CLA supplementation in healthy overweight individuals.

Main Methods:

  • A 12-week, double-blind, randomized controlled trial involving 40 healthy volunteers with BMI >27 kg/m2.

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  • Participants received either a CLA isomeric mixture or olive oil placebo.
  • Body fat assessed via computed tomography and skin-fold measurements; endothelial function by brachial artery flow-mediated dilatation (FMD); oxidative stress by plasma isoprostanes.

    • Main Results:

    • CLA supplementation did not significantly alter BMI or total body fat.
    • A significant reduction in limb subcutaneous fat was observed, but not in torso, abdominal, or liver fat.
    • Endothelial function (FMD) significantly declined, and plasma F2-isoprostanes (oxidative stress marker) significantly increased.

    Conclusions:

    • The CLA isomeric mixture demonstrated modest effects on adiposity but negatively impacted endothelial function.
    • The observed worsening of endothelial function and increase in oxidative stress suggest that CLA isomeric mixture is not advisable for weight loss purposes.
    • Further research is warranted to explore the long-term cardiovascular implications of CLA supplementation.