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Stabilized beta-catenin extends thymocyte survival by up-regulating Bcl-xL

Huimin Xie1, Zhaofeng Huang, Maureen S Sadim

  • 1Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|December 13, 2005
PubMed
Summary

Stabilizing beta-catenin enhances T cell survival by increasing Bcl-xL, a key protein that prevents apoptosis in CD4+CD8+ double-positive (DP) thymocytes. This finding offers new insights into thymocyte development and T cell immunity.

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