Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thalassemia: the continued challenge.

David G Nathan1

  • 1Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. David_Nathan@dfci.harvard.edu

Annals of the New York Academy of Sciences
|December 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correcting the record on anemia of aging: a statistical reanalysis.

Blood advances·2023
Same author

COVID-19, nuclear war, and global warming: lessons for our vulnerable world.

Lancet (London, England)·2020
Same author

The Genetic Landscape of Diamond-Blackfan Anemia.

American journal of human genetics·2019
Same author

The Genetic Landscape of Diamond-Blackfan Anemia.

American journal of human genetics·2018
Same author

The Pathophysiology of Acquired Aplastic Anemia: Current Concepts Revisited.

Hematology/oncology clinics of North America·2018
Same author

Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease.

Blood advances·2018
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

This overview covers the history of thalassemia treatment, focusing on iron overload management through chelation therapy and advancements like fetal hemoglobin induction. It also touches upon genetic diagnosis, stem cell transplants, and gene therapy for thalassemia.

Area of Science:

  • Hematology
  • Genetics
  • Pharmacology

Background:

  • Thalassemia necessitates regular blood transfusions, leading to iron overload.
  • Hepatic iron measurement is crucial for monitoring complications.

Discussion:

  • Chelation therapy has evolved significantly, with new oral agents offering improved patient compliance.
  • Understanding the genetic basis of thalassemia has enabled prenatal diagnosis.

Key Insights:

  • Pharmaceutical research focuses on inducing fetal hemoglobin synthesis to reduce transfusion dependence.
  • Stem cell transplantation and gene therapy represent potential cures for thalassemia.

Outlook:

  • Future directions include refining gene therapy approaches and developing more effective iron chelation strategies.

Related Experiment Videos

  • Integrated management strategies combining therapies are essential for improving patient outcomes.