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Updated: Aug 14, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major
Regine Grosse1, Ulrike Lund, Vincenzo Caruso
1University Medical Center Hamburg-Eppendorf, Department of Pediatric Hematology/Oncology, Martinistr. 52, Hamburg D-20246, Germany. regine_grosse@web.de
Abstract:
Serum non-transferrin-bound iron (NTBI) levels assessed at arbitrary time points during transfusion cycles may not be representative if NTBI is undergoing significant changes during transfusion cycles. In 15 patients with beta-thalassemia major (age: 21 +/- 6 years, liver iron concentration: 2200 +/- 1200 microg/g-liver), NTBI and other hematologic parameters (transferrin saturation, transferrin receptor) were measured weekly. The largest variation of NTBI levels between individual patients was observed at midcycle. For long-term monitoring of NTBI levels, a particular time point relative to the last blood transfusion should be selected for blood drawing.
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