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Thromboxane A2-induced arrhythmias in the anesthetized rabbit

Michael J Wacker1, Shaun R Best, Lisa M Kosloski

  • 1Dept. of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA. mjwacker@ku.edu

American Journal of Physiology. Heart and Circulatory Physiology
|December 13, 2005
PubMed
Summary

Thromboxane A(2) (TxA(2)) mimetic U-46619 causes ventricular arrhythmias in rabbits. This effect is TxA(2) receptor-mediated and independent of coronary blood flow or autonomic nerves, suggesting a direct cardiac effect.

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