Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The spermiological limits to ART].

P Barrière1

  • 1Médecine et Biologie de la Reproduction, CHU de Nantes, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|December 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum androgen dynamics in young women aged 18-40 treated with chemotherapy for breast cancer: an observational, multicentric, prospective study in France.

Human fertility (Cambridge, England)·2024
Same author

[Pre-implantation genetic testing: Comparison between cleavage stage and blastocyst biopsy].

Gynecologie, obstetrique, fertilite & senologie·2020
Same author

Evolution of serum Anti-Müllerian Hormone (AMH) level in young women treated with chemotherapy for breast cancer according to basal AMH level.

European journal of obstetrics, gynecology, and reproductive biology·2020
Same author

Female obesity does not impact live birth rate after frozen-thawed blastocyst transfer.

Human reproduction (Oxford, England)·2020
Same author

Development of automated annotation software for human embryo morphokinetics.

Human reproduction (Oxford, England)·2020
Same author

Ultrasonographic measures of body fatness and their relationship with plasma levels and adipose tissue expression of four adipokines in Welsh pony mares.

Domestic animal endocrinology·2019
Same journal

[Neuroprotection for preterm infants with antenatal magnesium sulphate].

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Is universal screening for cervical length among singleton pregnancies with no history of preterm birth justified?]

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Lifestyle recommendations for prevention of spontaneous preterm birth in asymptomatic pregnant women].

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Guidelines for clinical practice: Prevention of spontaneous preterm birth (excluding preterm premature rupture of membranes) - Introduction].

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Psychological aspects of abortion].

Journal de gynecologie, obstetrique et biologie de la reproduction·2016
Same journal

[Induced abortion: Guidelines for clinical practice - Introduction].

Journal de gynecologie, obstetrique et biologie de la reproduction·2016
See all related articles

Globozoospermia, a severe sperm defect, can impair in vitro fertilization (IVF) outcomes. Treating sperm DNA damage with antioxidants and timely intracytoplasmic sperm injection (ICSI) may improve fertility results.

Area of Science:

  • Reproductive biology and andrology.
  • Investigating male infertility factors.

Context:

  • Sperm defects like globozoospermia significantly impact in vitro fertilization (IVF) success.
  • Oxidative stress and sperm DNA fragmentation are implicated in male infertility and poor IVF outcomes.
  • Low sperm DNA and membrane integrity correlate with reduced fertility and implantation issues.

Purpose:

  • To highlight the challenges posed by globozoospermia and sperm DNA damage in IVF.
  • To discuss the role of oxidative stress in sperm pathologies.
  • To recommend therapeutic strategies for improving male fertility.

Summary:

  • Globozoospermia, a severe form of teratozoospermia, involves round-headed sperm lacking acrosomes, potentially leading to fertilization failure.
  • Sperm DNA fragmentation and oxidative stress are key contributors to male infertility.

Related Experiment Videos

  • Oral antioxidants and prompt intracytoplasmic sperm injection (ICSI) with testicular sperm are suggested interventions.

    • Impact:

    • Understanding these sperm defects is crucial for optimizing IVF protocols.
    • Antioxidant therapy shows promise in mitigating sperm DNA damage.
    • Timely ICSI with testicular sperm may enhance fertilization and pregnancy rates in specific cases.