Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cramp-fasciculation syndrome].

A Lagueny1

  • 1Service de Neurologie, USN Hôpital du Haut-Lévêque, Pessac. alain.lagueny@chu-bordeaux.fr

Revue Neurologique
|December 13, 2005
PubMed
Summary

Cramp-fasciculation syndrome, often benign, may rarely precede motor neuron disease. Antibodies to voltage-gated potassium channels (VGKCs) are implicated in related hyperexcitable peripheral nerve syndromes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parkinsonism in a patient with Leber hereditary optic neuropathy (LHON).

Revue neurologique·2015
Same author

Paraneoplastic dermatomyositis with glycogen accumulation in muscle.

Revue neurologique·2014
Same author

Usefulness of combined nerve and muscle biopsy in the diagnosis of amyloid neuropathy--a study of 6 new cases.

Clinical neuropathology·2010
Same author

Sarcoid neuropathy: clinico-pathological study of 4 new cases and review of the literature.

Clinical neuropathology·2008
Same author

[Lambert-Eaton Myasthenic Syndrome associated with vocal cord carcinoma].

Revue neurologique·2008
Same author

Retrobulbar optic neuritis: a complication of Lyme disease?

Journal of neurology, neurosurgery, and psychiatry·2007

Area of Science:

  • Neurology
  • Immunology

Context:

  • Cramp-fasciculation syndrome (CFS) is rare compared to isolated cramps or fasciculations.
  • CFS is typically benign, lacking weakness and atrophy, but may rarely herald motor neuron disease.
  • CFS can be part of a broader hyperexcitable peripheral nerve syndrome, potentially linked to voltage-gated potassium channel (VGKC) antibodies.

Purpose:

  • To explore the association between cramp-fasciculation syndrome and hyperexcitable peripheral nerve syndromes.
  • To investigate the role of voltage-gated potassium channel (VGKC) antibodies in these conditions.
  • To review the spectrum of anti-VGKC antibody-associated disorders and their management.

Summary:

  • CFS is usually idiopathic but can be a manifestation of peripheral nerve hyperexcitability, including Isaacs' syndrome.
  • Anti-VGKC antibodies are implicated in central nervous system disorders like Morvan's disease and limbic encephalitis, and can be associated with autoimmune diseases such as myasthenia gravis.
  • Treatments include carbamazepine and phenytoin for nerve hyperexcitability, while plasmapheresis and immunosuppressors are used for autoimmune causes.

Impact:

  • Expands the understanding of the anti-VGKC antibody syndrome spectrum.
  • Highlights potential links between CFS, autoimmune disorders, and neurological conditions.
  • Informs therapeutic strategies for managing nerve hyperexcitability and autoimmune-related neurological dysfunction.

Related Experiment Videos