Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

TGFbeta pathobiology in the eye.

Shizuya Saika1

  • 1Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan. shizuya@wakayama-med.ac.jp

Laboratory Investigation; a Journal of Technical Methods and Pathology
|December 13, 2005
PubMed
Summary

Transforming growth factor beta (TGFbeta) signaling regulates ocular cell behavior and development. Targeting Smad signals offers a potential therapeutic strategy for treating eye disorders involving fibrosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Muc16 contributes to protection against invasive pneumococcal infection originating from nasal colonization.

Microbiology spectrum·2026
Same author

Impact of the loss of tenascin X on tissue architecture and wound healing of the murine corneal stroma.

The ocular surface·2026
Same author

Aesthetic and functional outcomes following reconstruction of full-thickness lower eyelid defects using Hughes flap and orbicularis oculi muscle flap: A case series study.

JPRAS open·2026
Same author

Transconjunctival approach for involutional entropion: Impact on the ocular surface.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
Same author

Topical Rho kinase inhibitor rescues TRPV4 deficiency-induced an impairment of corneal epithelial wound healing by enhancing limbal stem cell proliferation.

Experimental eye research·2026
Same author

Color-Contrast Adjustment With a 3D Head-Up System to Aid Capsulorhexis After ICG Staining: Single-Patient Case Report From a Tertiary Center.

Case reports in ophthalmological medicine·2026

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Molecular Biology

Background:

  • Transforming growth factor beta (TGFbeta) is a key regulator of cell behavior in ocular tissues during development and repair.
  • Dysregulated TGFbeta activity can lead to inflammation and fibrosis in the eye.
  • Three TGFbeta isoforms (beta1, beta2, beta3) exist, with TGFbeta2 being crucial for embryonic eye development in mice.

Purpose of the Study:

  • To review recent advancements in understanding the role of TGFbeta signaling in ocular pathology.
  • To highlight the potential of targeting Smad signaling pathways for treating fibrotic eye diseases.

Main Methods:

  • Review of current literature on TGFbeta signaling in ocular tissues.
  • Analysis of Smad-dependent and Smad-independent signaling pathways involved in TGFbeta responses.
  • Discussion of therapeutic implications for fibrotic eye conditions.

Main Results:

  • TGFbeta signaling, particularly through Smad2/3 phosphorylation and nuclear translocation, plays a critical role in ocular development and disease.
  • Other kinases like MAPK, JNK, and p38 can modulate Smad signaling.
  • Specific TGFbeta isoforms have distinct roles, with TGFbeta2 deficiency impacting eye morphogenesis.

Conclusions:

  • Smad signaling is a pivotal pathway in ocular TGFbeta responses.
  • Targeting Smad signals presents a promising therapeutic avenue for ocular fibrotic diseases, analogous to systemic fibrotic conditions.

Related Experiment Videos