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Oncogenic PI3K deregulates transcription and translation

Andreas G Bader1, Sohye Kang, Li Zhao

  • 1Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Nature Reviews. Cancer
|December 13, 2005
PubMed

Insights

Phosphatidylinositol 3-kinase (PI3K) plays a key role in cancer development. Cancer-specific mutations in PIK3CA highlight the p110alpha subunit of PI3K as a promising therapeutic target for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Phosphatidylinositol 3-kinase (PI3K) signaling is implicated in cancer pathogenesis.
  • Deregulation of gene transcription and translation is essential for PI3K-driven oncogenic transformation.

Purpose of the Study:

  • To investigate the role of PI3K in cancer.
  • To highlight the p110alpha subunit as a potential drug target.

Main Methods:

  • Review of experimental data on PI3K in cancer.
  • Analysis of cancer-specific mutations in the PIK3CA gene.

Main Results:

  • Experimental evidence supports PI3K's role in oncogenesis.
  • Discovery of cancer-associated mutations in PIK3CA, encoding the p110alpha catalytic subunit.
  • Identification of p110alpha as a key mediator of PI3K-driven transformation.

Conclusions:

  • PI3K is a critical factor in cancer development.
  • The p110alpha subunit of PI3K, due to its frequent mutation in cancer, represents a viable therapeutic target.

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