Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

When do children convert from liquid antiretroviral to solid formulations?

Vincent W Yeung1, Ian C K Wong

  • 1Centre for Paediatric Pharmacy Research, The School of Pharmacy, The Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

Pharmacy World & Science : PWS
|December 13, 2005
PubMed
Summary

Children typically switch from liquid to solid antiretroviral formulations around age seven. Stavudine users tend to transition to solid forms earlier than those on other medications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Childhood Maltreatment and Adult Multimorbidity.

JAMA network open·2026
Same author

Psychiatric and neurological predictors of early ADHD medication discontinuation across the lifespan: a multinational study.

BMJ mental health·2026
Same author

A Target Trial Emulation to Investigate Kidney Protection from Statin Initiation in Adults with Normal Kidney Function.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Abrupt discontinuation and tapering of antipsychotics in older adults with dementia: a target trial emulation study.

The lancet. Healthy longevity·2026
Same author

Potential interactions between SSRIs and DOACs: population-based cohort and case-crossover study.

BJGP open·2026
Same author

Association between gabapentinoid treatment, concurrent use with opioid or benzodiazepine and the risk of drug poisoning: A self-controlled case series study.

PLoS medicine·2026

Area of Science:

  • Paediatric pharmacology
  • Clinical pharmacy
  • HIV/AIDS treatment

Background:

  • Liquid antiretroviral formulations are standard for children but present challenges like stability, taste, and travel inconvenience.
  • Solid formulations offer a preferred alternative for long-term management in older children, parents, and clinicians.
  • Limited research exists on the optimal age for transitioning children from liquid to solid antiretroviral drug forms.

Purpose of the Study:

  • To determine the age range for converting children from liquid to solid antiretroviral formulations (abacavir, didanosine, lamivudine, stavudine, zidovudine).
  • To assess the retention time of five UK-based liquid antiretroviral formulations and identify factors influencing it.

Main Methods:

  • A retrospective survey of medical records at Great Ormond Street Hospital for Children, London.

Related Experiment Videos

  • Calculation of retention times from liquid treatment initiation to solid formulation conversion using SPSS software.
  • Comparison of retention times across different antiretroviral preparations via Cox regression analysis.

    • Main Results:

    • Analysis included 92 pediatric patients.
    • The average age for conversion to solid formulations was 7.3 years.
    • Patients on stavudine showed a significantly higher likelihood (P < 0.001) of switching to solid forms earlier than those on other medications; over 50% switched within nine months, compared to less than 25% for others.

    Conclusions:

    • Children generally transition to solid antiretroviral dosage forms around seven years of age.
    • Stavudine is associated with an earlier switch to solid formulations in pediatric patients.