A LabVIEW model incorporating an open-loop arterial impedance and a closed-loop circulatory system

Area of Science:

• Cardiovascular Physiology
• Computational Biology
• Biomedical Engineering

Background:

• Existing computer models of the circulatory system often lack versatility or include specialized components.
• A need exists for a foundational yet comprehensive model applicable to diverse research and educational settings.

Purpose of the Study:

• To develop a basic, multifaceted computer model of the left heart and systemic circulation in LabVIEW.
• To create a universally applicable model that retains essential physiological features.

Main Methods:

• Utilized Windkessel-type impedance models in open-loop configurations.
• Developed a closed-loop model integrating a lumped impedance and a ventricular pressure source.
• Incorporated a basic coronary circuit for expanded ventricular equation utility.

Main Results:

• Open-loop models effectively demonstrated afterload effects on aortic pressure/flow.
• The closed-loop model successfully cataloged major circulatory waveforms under varying afterload, preload, and left heart conditions.
• Model outputs for afterload parameter changes align with established physiological data.

Conclusions:

• The developed LabVIEW model provides a user-friendly platform for altering circulatory factors.
• It digitally catalogs key pressure/flow waveform features, serving as a valuable instructional and research tool.
• The model facilitates the expansion of ventricular equation applications within a coupled circulatory system.