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Updated: Aug 14, 2026

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
Published on: August 11, 2021
Is the platelet serotonin transporter different in venous vs. arterial blood?
Emiliano Villa1, Claudio Albano, Andrea Cappelli
1Molecular Physiology and Bioimaging Institute, CNR, Sezione di Genova, Via De Toni 5, 16132, Genova, Italy.
Abstract:
The binding of labelled paroxetine to the serotonin transporter (SERT) of platelet membranes has been studied in both venous and mixed venous/arterial blood of the rat. In addition, we studied the inhibition of paroxetine binding to SERT by quipazine and N-methyl-quipazine (NMQ). The results indicate differences in affinity for the two test drugs, quipazine and NMQ, in venous vs. mixed venous/arterial blood. This suggests different post-translational modifications of SERT in platelets of arterial vs. venous blood.
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