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Updated: Aug 14, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
Published on: January 26, 2024
A distributed computation of Interpro Pfam, PROSITE and ProDom for protein annotation
Edward de O Ribeiro1, Gustavo G Zerlotini, Irving R M Lopes
1Departamento de Ciência da Computação, Universidade de Brasília, Brasília, DF, Brazil. edward@cic.unb.br
Abstract:
Interpro is a widely used tool for protein annotation in genome sequencing projects, demanding a large amount of computation and representing a huge time-consuming step. We present a strategy to execute programs using databases Pfam, PROSITE and ProDom of Interpro in a distributed environment using a Java-based messaging system. We developed a two-layer scheduling architecture of the distributed infrastructure. Then, we made experiments and analyzed the results. Our distributed system gave much better results than Interpro Pfam, PROSITE and ProDom running in a centralized platform. This approach seems to be appropriate and promising for highly demanding computational tools used for biological applications.
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