Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A method for multitask fMRI data fusion applied to schizophrenia.

Vince D Calhoun1, Tulay Adali, Kent A Kiehl

  • 1Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06106, USA. vince.calhoun@yale.edu

Human Brain Mapping
|December 13, 2005
PubMed
Summary

Schizophrenia patients show decreased connectivity in joint brain networks and activate more similarly across tasks compared to controls. This novel analysis of functional magnetic resonance imaging (fMRI) data reveals insights into brain function and pathology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis.

Schizophrenia bulletin open·2026
Same author

Associations of social and genetic background variables to neuro-cognitive biomarkers of psychosis.

Biomarkers in neuropsychiatry·2026
Same author

Behavioral Inhibition Network Predicts Alcohol Use in Men and Stress in Women.

Journal of studies on alcohol and drugs·2026
Same author

Family-Level Brain Pattern Similarities and Their Clinical Significance in Young Offspring of Individuals With Psychotic Disorders.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Premorbid adjustment problems, negative symptoms, and cognitive impairment in a large international sample at clinical high risk for psychosis: Findings from the Accelerating Medicines Partnership-Schizophrenia.

Schizophrenia bulletin·2026
Same author

Brain functional network connectivity interpolation characterizes the neuropsychiatric continuum and heterogeneity.

Imaging neuroscience (Cambridge, Mass.)·2026

Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Psychiatric Disorders

Background:

  • Functional magnetic resonance imaging (fMRI) data from multiple paradigms are increasingly collected per individual.
  • Traditional analysis methods often examine tasks separately or via direct subtraction, limiting the exploration of commonalities.
  • Existing approaches do not fully leverage the potential for integrated analysis across tasks and voxels.

Purpose of the Study:

  • To propose and demonstrate a novel method for extracting spatially independent maps across multiple fMRI tasks.
  • To identify shared and distinct neural network patterns between tasks within individuals.
  • To investigate functional brain connectivity and activation patterns in schizophrenia patients compared to healthy controls during cognitive tasks.

Main Methods:

Related Experiment Videos

  • Computed individual activation maps for each task as features.
  • Performed joint independent component analysis (jICA) on group data to extract coupled spatial maps.
  • Applied the method to fMRI data from healthy controls and schizophrenia patients performing an auditory oddball and a Sternberg working memory task.

Main Results:

  • Schizophrenia patients exhibited decreased connectivity in a joint network relevant to schizophrenia models.
  • The correlation between activation patterns for the two tasks was significantly higher in patients than controls.
  • This suggests schizophrenia patients activate more similarly across different tasks, potentially with less unique regional engagement.

Conclusions:

  • Joint analysis of multi-task fMRI data reveals novel findings missed by traditional methods.
  • The findings support the hypothesis of altered network connectivity and more similar task activation in schizophrenia.
  • This approach enhances the understanding of coordinated brain networks and the impact of psychopathology.